SkinPen® Precision and Mottled Hyperpigmented Lesions/Patches
Introduction to Mottled Hyperpigmented
Lesions/Patches:
Common skin condition with unknown cause.
This skin condition is not a mystery. It’s linked to both solar exposure and hormonally activated melanocytes, which lead to an uneven increase in facial melanin by boosting melanocyte stimulation hormone (MSH).
This skin condition is more prevalent in individuals with higher pigmentation but can affect all skin types.
V. Sheth et al, JAAD (2010) https://doi.org/10.1016/j.jaad.2010.12.046
Mechanism of Action:
Induce keratinocyte turnover and “restore” the normal pigment activity of melanocytes in over pigmented areas.
This occurs at the dermal-epidermal junction (DEJ).
This DEJ-shallow dermis area is the target depth to microneedle. See arrows where microchannels are formed
EPIDERMAL MELANIN DENSITY IN MELASMA BEFORE PROCEDURE
REDUCTION IN EPIDERMAL MELANIN DENSITY 1 WEEK AFTER MICRONEEDLING PROCEDURE
Cassiano et al., Indian Journal of Dermatology, Venereology and Leprology | Volume 85 | Issue 6 | November-December 2019
SkinPen® Precision and Pigmentation Conditions
Introduction to Pigmentation Conditions:
Solar lentigines occur due to excessive production of melanin pigment which results from overexposure to UV rays from the sunlight or tanning beds
Crown Aesthetics, data on file ; Global Aesthetic Improvement Scale (GAIS)
Mechanism of Action:
Induce keratinocyte turnover and “restore” the normal pigment activity of melanocytes in over pigmented areas.
This occurs at the dermal-epidermal junction (DEJ).
This DEJ-shallow dermis area is the target depth to microneedle. See arrows where microchannels are formed
Courtesy of Rosenpark Research, Dr. Sonja Sattler
SkinPen® Precision and Hypopigmented patches
Introduction to Hypopigmented patches:
Introduction to
Hypopigmented patches:
Hypopigmented patches occurs when pigment-producing cells (melanocytes) die or stop producing melanin.
The involved patches of skin become lighter or white. It’s unclear exactly what causes these pigment cells to fail or die.
It may be related to:
A disorder of the immune system (autoimmune condition)
Family history (heredity)
A trigger event, such as stress, severe sunburn or skin trauma, such as contact with a chemical
Mechanism of Action:
Induce the activation, migration, and/or proliferation of melanocytes into hypopigmented areas at the dermal-epidermal(DEJ). This shallow dermis area is the target depth.
Also, mechanical trauma stimulates the melanocytes migration from the pigmented areas to unpigmented areas.
Microneedling may increase the number of pigment cells and stimulate more pigment production Studies in literature indicate that 6 or more treatments may be necessary to begin to see improvement
